Table 6.
TNFα levels in peripheral blood at 2 h after initiation of MDX-447 infusion (day 1)
| Dose (mg/m2) | TNFα (pg/ml) | |
|---|---|---|
| Group 1 | Group 2 | |
| 1.0 | ||
| Mean (n) | 45.1 (6) | 577.6 (3) |
| SEM | 12.3 | 241.5 |
| 3.5 | ||
| Mean (n) | 196.5 (6) | 992.3 (6) |
| SEM | 63.1 | 349.2 |
| 7.0 | ||
| Mean (n) | 9.9 (3) | 628.2 (4) |
| SEM | 4.4 | 415.3 |
| 10.0 | ||
| Mean (n) | 16.4 (3) | 1,713.5 (7) |
| SEM | 9.2 | 566.3 |
| 15.0 | ||
| Mean (n) | 20.1 (6) | 58.4 (2) |
| SEM | 4.7 | 56.8 |
| 20.0 | ||
| Mean (n) | 40.6 (6) | |
| SEM | 12.0 | |
| 30.0 | ||
| Mean (n) | 24.2 (6) | |
| SEM | 6.7 | |
| 40.0 | ||
| Mean (n) | 40.3 (4) | |
| SEM | 21.3 | |
n number of subjects, pg picogram, SEM standard error of the mean