Table 1.
Patient characteristics and the rate of abnormal TCR BV gene families
| Case | Sex | Age | Diagnose of cancer | Treatment protocol | ECOG score | Evaluation | Rate of abnormal TCR BV gene families (%) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Type of cancer | Sites of metastasis | Baseline | After 1st cycle | After 2nd cycle | After 3rd cycle | After 4th cycle | Imaging | CD4+ T cells | CD8+ T cells | |||||||||||||
| After 1st cycle | After 2nd cycle | After 3rd cycle | After 4th cycle | Baseline | After 1st cycle | After 2nd cycle | After 3rd cycle | Baseline | After 1st cycle | After 2nd cycle | After 3rd cycle | |||||||||||
| JYF | Male | 69 | Rectal | Lung, lymph nodes | mIFL + Avastin | 1 | 1 | 1 | 1 | 1 | SD | SD | SD | SD | 50 | 37.5 | 25 | 66.7 | 62.5 | 54.2 | ||
| LQT | Male | 40 | Colon | Liver, others | mIFL + Avastin | 1 | 1 | 1 | 1 | SD | SD | PD | 62.5 | 58.3 | 58.3 | 54.2 | 70.8 | 66.7 | 62.5 | 66.7 | ||
| ZWT | Male | 46 | Colon | Liver, lymph nodes | mIFL + Avastin | 1 | 1 | 1 | 1 | SD | SD | SD | 41.7 | 37.5 | 29.2 | 37.5 | 33.3 | 20.8 | ||||
| ZQ | Female | 61 | Colon | Liver | mIFL + Avastin | 1 | 1 | PR | 58.3 | 33.3 | 83.3 | 37.5 | ||||||||||
| CJN | Male | 48 | Colon | Lung, liver, others | mIFL + Avastin | 1 | 1 | 1 | 1 | SD | SD | SD | 37.5 | 33.3 | 29.2 | 20.8 | 45.8 | 41.7 | 41.7 | 37.5 | ||
| ZXH | Male | 40 | Rectal | Lung, liver | mIFL + Avastin | 1 | 1 | 1 | SD | PD | 50 | 41.7 | 29.2 | 58.3 | 54.2 | 41.7 | ||||||
| DYL | Male | 51 | Rectal | Lung, others | mIFL + Avastin | 1 | 1 | SD | 33.3 | 29.2 | 45.8 | 41.7 | ||||||||||
| LZX | Male | 62 | Colon | Liver | mIFL + Avastin | 1 | 1 | 1 | 1 | 1 | SD | SD | SD | SD | 58.3 | 54.2 | 50 | 70.8 | 66.7 | 66.7 | ||
| LQY | Male | 55 | Rectal | Lung, liver, others | mIFL + Avastin | 1 | 1 | PD | 50 | 58.3 | 62.5 | 66.7 | ||||||||||
| HYH | Female | 52 | Colon | Liver, others | mIFL + Avastin | 1 | 1 | 1 | 2 | PR | PR | PD | 66.7 | 45.8 | 45.8 | 79.2 | 54.2 | 58.3 | ||||
| DQ | Male | 57 | Rectal | Lung | mIFL + Avastin | 1 | 1 | 1 | 1 | 1 | SD | SD | PR | PR | 50 | 45.8 | 33.3 | 62.5 | 58.3 | 50 | ||
| LSY | Female | 61 | Rectal | Lymph nodes, others | mIFL + Avastin | 1 | 1 | 1 | 1 | 1 | SD | SD | SD | SD | 33.3 | 25 | 20.8 | 62.5 | 58.3 | 45.8 | ||
| XWJ | Female | 40 | Rectal | Lung, liver, others | mIFL | 1 | 2 | PD | 62.5 | 58.3 | 62.5 | 66.7 | ||||||||||
| LQZ | Male | 36 | Colon | Lymph nodes, others | mIFL | 1 | 1 | 1 | 2 | SD | SD | SD | SD | 58.3 | 54.2 | 62.5 | 66.7 | 62.5 | 70.8 | |||
| LST | Female | 49 | Rectal | Liver, others | mIFL | 1 | 1 | 1 | 2 | SD | SD | SD | SD | 54.2 | 50 | 50 | 45.8 | 62.5 | 54.2 | 58.3 | 58.3 | |
| LHS | Male | 45 | Rectal | Lymph nodes, others | mIFL | 1 | 1 | 2 | SD | PD | 37.5 | 45.8 | 45.8 | 58.3 | ||||||||
| LHJ | Female | 38 | Colon | Liver | mIFL | 1 | 1 | SD | 54.2 | 50 | 62.5 | 62.5 | ||||||||||
| HLZ | Female | 47 | Colon | Lymph nodes, others | mIFL | 1 | 1 | 1 | 1 | SD | SD | SD | SD | 45.8 | 50 | 54.2 | 54.2 | 58.3 | 58.3 | |||