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. 2006 Jan 25;55(11):1358–1366. doi: 10.1007/s00262-006-0123-0

Table 1.

Relative binding affinity of HER-2/neu-derived peptides to HLA-A24

Peptide Sequence A24 binding2 IC50
Wild type peptide
HER-2(8) RWGLLLALL 11.41
HER-2(780) PYVSRLLGI 77.14
HER-2(951) VYMIMVKCW 79.93
HER-2(440) AYSLTLQGL 97.98
HER-2(907) SYGVTVWEL 101.42
HER-2(905) VWSYGVTVW 173.21
HER-2(63) TYLPTNASL 323.50
HER-2(968) RFRELVSEF 744.21
HER-2(342) CYGLGMEHL 780.14
HER-2(887) KWMALESIL 887.79
Substitution analog
HER-2(8AA) RYGLLLALF 1.47
HER-2(780A) PYVSRLLGF 9.23
HER-2(905AA) VYSYGVTVF 17.89
HER-2(887AA) KYMALESIF 19.97
HER-2(951A) VYMIMVKCF 19.98
HER-2(907A) SYGVTVWEF 27.82
HER-2(968A) RYRELVSEF 37.21
HER-2(414AA) AYPDSLPDF 42.97
HER-2(63A) TYLPTNASF 46.02