Table 1.
Relative binding affinity of HER-2/neu-derived peptides to HLA-A24
| Peptide | Sequence | A24 binding2 IC50 |
|---|---|---|
| Wild type peptide | ||
| HER-2(8) | RWGLLLALL | 11.41 |
| HER-2(780) | PYVSRLLGI | 77.14 |
| HER-2(951) | VYMIMVKCW | 79.93 |
| HER-2(440) | AYSLTLQGL | 97.98 |
| HER-2(907) | SYGVTVWEL | 101.42 |
| HER-2(905) | VWSYGVTVW | 173.21 |
| HER-2(63) | TYLPTNASL | 323.50 |
| HER-2(968) | RFRELVSEF | 744.21 |
| HER-2(342) | CYGLGMEHL | 780.14 |
| HER-2(887) | KWMALESIL | 887.79 |
| Substitution analog | ||
| HER-2(8AA) | RYGLLLALF | 1.47 |
| HER-2(780A) | PYVSRLLGF | 9.23 |
| HER-2(905AA) | VYSYGVTVF | 17.89 |
| HER-2(887AA) | KYMALESIF | 19.97 |
| HER-2(951A) | VYMIMVKCF | 19.98 |
| HER-2(907A) | SYGVTVWEF | 27.82 |
| HER-2(968A) | RYRELVSEF | 37.21 |
| HER-2(414AA) | AYPDSLPDF | 42.97 |
| HER-2(63A) | TYLPTNASF | 46.02 |