Figure 6.

Conversion of tumor cell phenotype is more critical for tumor control than T cell phenotype preservation

(A) Theoretical sketch of how T cells are able to escape the tumor microenvironment to promote long-term survival and ability to control the tumor.

(B) Snapshots of the tumor from agent-based modeling of a tumor treated with 25% PD-1⁺ T cells that were initialized outside the tumor such that they can escape chronic exposure to tumor and limit exhaustion.

(C) Total number of T cells over time of simulation when T cells are initialized outside the tumor bed or inside the tumor.

(D) Total number of tumor cells over time of simulation when T cells are initialized outside the tumor bed or inside the tumor.

(E) Number of tumor cells separated by phenotype over the course of the simulation.

(F) Number of tumor cell deaths over the time course of the simulation.

For (C)–(F), mean of n = 4 replicates with shading showing SEM.