Table 4.
Univariate and multivariate analyzes including pT- and pN-category, histologic grade, HER2 gene-status, EGFR, estrogen receptor, NY-BR-1 and HLA class I for overall survival
| Variables | Univariate | multivariate | ||||
|---|---|---|---|---|---|---|
| n | Hazard ratio (95% CI)a | P value | n | Hazard ratio (95% CI)a | P value | |
| pT | 1,033 | 1.72 (1.54–1.92) | <0.0001 | 728 | 1.78 (1.53–2.06) | <0.0001 |
| pN | 740 | 1.61 (1.36–1.90) | <0.0001 | 728 | 1.38 (1.15–1.65) | 0.0005 |
| Histologic grade | 1,023 | 1.62 (1.34–1.96) | <0.0001 | 728 | 1.46 (1.13–1.88) | 0.003 |
| EGFR | 1,038 | 1.45 (1.12–1.87) | 0.005 | 728 | 1.91 (1.39–2.61) | 0.0001 |
| HER2 gene-status | 1,038 | 1.90 (1.41–2.57) | 0.0001 | 728 | 1.59 (1.12–2.24) | 0.009 |
| Estrogen receptor | 1,038 | 0.55 (0.42–0.72) | 0.0001 | 728 | – | NS |
| NY-BR-1 | 1,038 | 0.74 (0.59–0.96) | 0.015 | 728 | – | NS |
| HLA class I | 1,038 | – | NS | 728 | – | NS |
NS not significant
aincrease of hazard for one stage (pT, pN, histologic grade) or negative to positive (EGFR, HER2-status, estrogen receptor, NY-BR-1, HLA class I)