Table 1.
Mean MAP analyte concentrations in the serum of patients treated with 30 μg/kg rIL-21 using the 5 + 9 dosing regimen (n = 12)
| Analyte (units) | Average serum concentration (SD) | |||||
|---|---|---|---|---|---|---|
| Day 1 | Day 5 | Day 8 | Day 15 | Day 19 | Day 22 | |
| Adiponectin (μg/mL) | 3.75 (2.03) | 3.06 (1.67) | 2.63 (1.20) | 3.74 (2.00) | 2.96 (1.46) | 2.49 (1.08) |
| Alpha-1 antitrypsin (mg/mL) | 1.83 (0.375) | 2.97 (0.478) | 3.40 (0.657) | 2.41 (0.579) | 3.27 (0.669) | 3.29 (0.641) |
| Alpha-2 macroglobulin (mg/mL) | 0.728 (0.334) | 0.620 (0.107) | 0.689 (0.372) | 0.600 (0.264) | 0.480 (0.307) | 0.609 (0.341) |
| Alpha-fetoprotein (ng/mL) | 2.50 (1.95) | 2.25 (1.17) | 2.62 (1.67) | 2.48 (2.15) | 1.70 (0.872) | 2.28 (1.47) |
| Apolipoprotein A1 (mg/mL) | 0.342 (0.099) | 0.176 (0.089) | 0.134 (0.062) | 0.320 (0.069) | 0.163 (0.080) | 0.138 (0.051) |
| Apolipoprotein CIII (μg/mL) | 98.4 (47.6) | 76.6 (105) | 74.1 (43.0) | 122 (52.9) | 54.4 (28.8) | 76.3 (21.6) |
| Apolipoprotein H (μg/mL) | 266 (79.3) | 224 (58.0) | 241 (79.1) | 264 (68.1) | 221 (63.0) | 237 (71.8) |
| Beta-2 microglobulin (μg/mL) | 2.48 (0.751) | 4.51 (1.27) | 4.62 (1.37) | 3.14 (0.861) | 5.20 (1.41) | 4.94 (1.17) |
| Brain-derived neurotrophic factor (ng/mL) | 15.6 (3.96) | 7.49 (2.85) | 7.48 (2.70) | 14.5 (5.05) | 7.50 (2.63) | 7.62 (2.42) |
| C Reactive protein (μg/mL) | 4.77 (3.59) | 81.4 (5.85) | 70.4 (21.5) | 14.0 (21.7) | 96.0 (41.6) | 72.0 (15.7) |
| Cancer antigen 19-9 (U/mL) | 1.44 (0.828) | 1.23 (0.774) | 1.09 (0.509) | 1.30 (0.557) | 1.12 (0.449) | 0.979 (0.604) |
| Complement 3 (mg/mL) | 1.20 (0.198) | 1.66 (0.751) | 1.46 (0.250) | 1.30 (0.256) | 1.44 (0.215) | 1.46 (0.214) |
| EGF (pg/mL) | 47.5 (43.4) | 17.3 (12.8) | 42.1 (44.4) | 91.0 (85.4) | 50.4 (49.1) | 50.9 (59.9) |
| ENA-78 (ng/mL) | 1.47 (0.718) | 0.940 (0.636) | 0.667 (0.427) | 2.68 (1.74) | 0.966 (0.736) | 0.776 (0.516) |
| Eotaxin (pg/mL) | 83.7 (32.4) | 35.9 (19.4) | 58.2 (30.6) | 95.1 (32.1) | 44.2 (21.1) | 54.8 (22.2) |
| Factor VII (ng/mL) | 400 (73.5) | 296 (99.9) | 316 (134) | 401 (160) | 298 (157) | 334 (132) |
| Ferritin (ng/mL) | 210 (196) | 688 (330) | 1270 (1070) | 451 (300) | 999 (766) | 1040 (603) |
| ICAM-1 (ng/mL) | 114 (22.8) | 170 (27.7) | 179 (26.7) | 151 (33.0) | 182 (29.3) | 172 (26.2) |
| IgA (mg/mL) | 2.72 (1.26) | 2.99 (1.42) | 3.04 (1.26) | 2.93 (1.32) | 2.79 (1.20) | 3.09 (1.27) |
| IgE (ng/mL) | 130 (212) | 186 (293) | 108 (125) | 215 (397) | 195 (282) | 142 (147) |
| IgM (mg/mL) | 0.972 (0.346) | 1.17 (0.994) | 0.933 (0.290) | 0.862 (0.280) | 0.816 (0.278) | 0.847 (0.325) |
| IL-10 (pg/mL) | 4.17 (3.14) | 123 (71.8) | 14.6 (11.6) | 3.76 (3.22) | 91.1 (35.3) | 6.44 (4.07) |
| IL-15 (ng/mL) | 1.30 (0.808) | 1.31 (1.31) | 4.52 (3.17) | 2.57 (2.09) | 3.48 (3.26) | 3.67 (3.37) |
| IL-16 (pg/mL) | 546 (222) | 902 (373) | 1030 (320) | 781 (188) | 1160 (289) | 1080 (263) |
| IL-18 (pg/mL) | 273 (110) | 551 (179) | 823 (328) | 531 (223) | 913 (335) | 964 (399) |
| IL-8 (pg/mL) | 6.75 (3.83) | 13.3 (9.70) | 8.33 (4.12) | 22.0 (36.3) | 42.7 (91.9) | 28.9 (64.0) |
| Lipoprotein (a) (μg/mL) | 188 (173) | 178 (174) | 109 (96.7) | 106 (81.3) | 107 (92.6) | 83.9 (73.7) |
| MCP-1 (pg/mL) | 170 (98.9) | 418 (289) | 168 (93.4) | 148 (67.2) | 393 (322) | 141 (57.6) |
| MDC (pg/mL) | 478 (117) | 570 (321) | 1340 (1100) | 998 (653) | 1180 (1280) | 1280 (1270) |
| MIP-1alpha (pg/mL) | 15.2 (13.9) | 24.3 (17.5) | 19.9 (6.07) | 30.1 (20.7) | 27.0 (15.6) | 20.0 (8.07) |
| MIP-1beta (pg/mL) | 179 (56.4) | 234 (69.1) | 200 (53.9) | 193 (99.5) | 208 (69.2) | 157 (55.2) |
| MMP-3 (ng/mL) | 8.58 (3.32) | 7.40 (2.75) | 7.89 (3.39) | 7.68 (3.45) | 6.21 (2.22) | 6.79 (2.52) |
| Myoglobin (ng/mL) | 13.3 (7.48) | 15.5 (14.6) | 20.3 (21.9) | 11.7 (4.66) | 17.4 (11.8) | 26.3 (25.3) |
| PAI-1 (ng/mL) | 118 (28.9) | 74.2 (25.4) | 92.6 (42.5) | 150 (47.2) | 76.5 (24.6) | 90.3 (35.0) |
| RANTES (ng/mL) | 22.1 (5.39) | 14.3 (6.18) | 17.4 (8.08) | 40.9 (18.9) | 15.7 (6.90) | 17.5 (5.15) |
| Serum amyloid P (μg/mL) | 36.7 (7.10) | 35.7 (3.19) | 38.0 (4.06) | 33.3 (7.39) | 36.8 (5.45) | 35.4 (7.39) |
| Stem cell factor (pg/mL) | 101 (62.8) | 81.2 (63.5) | 47.0 (22.5) | 170 (150) | 76.8 (51.4) | 49.4 (29.0) |
| TIMP-1 (ng/mL) | 192 (42.4) | 258 (44.5) | 271 (62.6) | 261 (68.3) | 249 (39.9) | 237 (38.8) |
| TNF RII (ng/mL) | 51.9 (51.8) | 255 (249) | 274 (231) | 74.9 (71.8) | 298 (290) | 252 (201) |
| TNF-alpha (pg/mL) | 4.56 (2.08) | 7.79 (2.28) | 7.05 (2.23) | 5.10 (3.04) | 6.82 (2.89) | 6.78 (2.45) |
| VCAM-1 (ng/mL) | 500 (126) | 930 (187) | 1070 (241) | 675 (235) | 1030 (265) | 1040 (238) |
| VEGF (pg/mL) | 355 (147) | 422 (158) | 423 (220) | 497 (241) | 418 (171) | 410 (175) |
| von Willebrand factor (μg/mL) | 26.1 (10.4) | 63.2 (11.4) | 57.4 (13.3) | 34.9 (11.2) | 64.9 (15.4) | 53.3 (11.6) |