Table 2.
Mean MAP analyte concentrations in the serum of patients treated with 30 μg/kg rIL-21 using the 3/w dosing regimen (n = 7)
| Analyte (units) | Average serum concentration (SD) | |||
|---|---|---|---|---|
| Day 1 | Day 5 | Day 15 | Day 19 | |
| Adiponectin (μg/mL) | 3.84 (1.55) | 3.14 (1.29) | 2.87 (0.972) | 2.76 (0.960) |
| Alpha-1 antitrypsin (mg/mL) | 2.18 (0.735) | 2.70 (0.779) | 3.06 (0.765) | 3.30 (0.697) |
| Alpha-2 macroglobulin (mg/mL) | 0.985 (0.235) | 1.03 (0.268) | 0.862 (0.299) | 0.829 (0.335) |
| Alpha-fetoprotein (ng/mL) | 2.68 (0.874) | 2.49 (0.881) | 2.41 (0.953) | 2.05 (0.772) |
| Apolipoprotein A1 (mg/mL) | 0.499 (0.177) | 0.286 (0.132) | 0.208 (0.0730) | 0.211 (0.0921) |
| Apolipoprotein CIII (μg/mL) | 101 (35.6) | 62.2 (23.7) | 81.2 (38.9) | 89.9 (64.8) |
| Apolipoprotein H (μg/mL) | 254 (65.1) | 216 (31.7) | 230 (69.3) | 228 (55.7) |
| Beta-2 microglobulin (μg/mL) | 1.91 (0.281) | 3.16 (0.475) | 3.82 (0.777) | 4.46 (1.34) |
| Brain-derived neurotrophic factor (ng/mL) | 14.7 (7.93) | 5.89 (2.28) | 6.09 (3.70) | 5.38 (2.53) |
| C Reactive protein (μg/mL) | 7.22 (9.94) | 83.7 (38.0) | 45.7 (17.5) | 64.7 (25.5) |
| Cancer antigen 19-9 (U/mL) | 5.12 (4.96) | 4.65 (5.84) | 7.38 (11.9) | 3.87 (4.49) |
| Complement 3 (mg/mL) | 1.45 (0.296) | 1.72 (0.338) | 1.62 (0.253) | 1.74 (0.310) |
| EGF (pg/mL) | 123 (171) | 90.4 (155) | 134 (208) | 107 (191) |
| ENA-78 (ng/mL) | 2.21 (0.747) | 1.62 (0.987) | 1.72 (1.02) | 1.71 (0.969) |
| Eotaxin (pg/mL) | 114 (44.1) | 82.9 (52.1) | 97.1 (54.5) | 91.0 (59.2) |
| Factor VII (ng/mL) | 495 (368) | 313 (157) | 349 (257) | 249 (155) |
| Ferritin (ng/mL) | 226 (239) | 363 (262) | 533 (476) | 669 (583) |
| ICAM-1 (ng/mL) | 135 (22.5) | 164 (20.9) | 179 (36.9) | 155 (16.6) |
| IgA (mg/mL) | 2.76 (1.09) | 2.60 (0.854) | 2.79 (1.01) | 2.98 (1.06) |
| IgE (ng/mL) | 99.5 (164) | 155 (244) | 154 (208) | 154 (259) |
| IgM (mg/mL) | 1.12 (0.452) | 1.08 (0.406) | 0.922 (0.264) | 0.951 (0.377) |
| IL-10 (pg/mL) | 2.41 (1.50) | 12.7 (6.06) | 3.41 (2.68) | 6.53 (5.70) |
| IL-15 (ng/mL) | 0.413 (0.224) | 0.252 (0.232) | 0.485 (0.422) | 0.180 (0.181) |
| IL-16 (pg/mL) | 438 (192) | 600 (292) | 763 (503) | 627 (189) |
| IL-18 (pg/mL) | 229 (129) | 382 (158) | 699 (275) | 822 (457) |
| IL-8 (pg/mL) | 20.0 (16.1) | 28.5 (37.5) | 25.2 (28.5) | 28.6 (27.6) |
| Lipoprotein (a) (μg/mL) | 47.8 (20.7) | 45.9 (17.2) | 38.8 (15.2) | 38.6 (15.5) |
| MCP-1 (pg/mL) | 197 (109) | 231 (97.7) | 184 (165) | 149 (68.2) |
| MDC (pg/mL) | 365 (78.8) | 334 (74.0) | 485 (221) | 382 (128) |
| MIP-1alpha (pg/mL) | 23.7 (9.08) | 30.7 (8.52) | 39.3 (17.5) | 35.3 (17.8) |
| MIP-1beta (pg/mL) | 193 (59.9) | 257 (104) | 171 (67.5) | 173 (63.5) |
| MMP-3 (ng/mL) | 6.86 (2.57) | 6.07 (2.49) | 8.70 (6.68) | 5.49 (2.37) |
| Myoglobin (ng/mL) | 11.1 (4.10) | 11.4 (4.72) | 14.6 (6.74) | 25.4 (14.9) |
| PAI-1 (ng/mL) | 146 (49.8) | 103 (26.6) | 126 (48.2) | 108 (27.9) |
| RANTES (ng/mL) | 26.2 (5.33) | 18.3 (7.06) | 24.0 (17.1) | 21.1 (9.93) |
| Serum amyloid P (μg/mL) | 38.5 (6.10) | 42.5 (5.43) | 42.1 (7.71) | 41.2 (7.21) |
| Stem cell factor (pg/mL) | 188 (98.0) | 136 (97.0) | 140 (101) | 116 (116) |
| TIMP-1 (ng/mL) | 185 (48.3) | 191 (40.8) | 213 (63.0) | 212 (49.0) |
| TNF RII (ng/mL) | 20.9 (31.2) | 73.9 (109) | 77.3 (110) | 102 (144) |
| TNF-alpha (pg/mL) | 3.21 (1.98) | 5.47 (0.748) | 5.23 (3.12) | 4.59 (1.99) |
| VCAM-1 (ng/mL) | 513 (175) | 814 (338) | 986 (291) | 998 (369) |
| VEGF (pg/mL) | 339 (85.8) | 363 (121) | 469 (265) | 356 (131) |
| von Willebrand factor (μg/mL) | 23.5 (7.89) | 55.9 (6.06) | 57.1 (7.54) | 65.2 (14.7) |