Fig. 2.
CD4 T cell responses against predicted peptide epitopes derived from Aurora-A. a Production of GM-CSF by HTL clone MT16 (from a DR9/14, DQ7/9 donor) when stimulated with various doses of peptide Aurora-A161–175 (this clone did not produce IFN-γ when stimulated with antigen). b Peptide Aurora-A161–175 induces production of IFN-γ by HTL clones Sa11 (DR4/15, DQ1/4 donor) and 4E (DR4/9, DQ7/8 donor). c Production of IFN-γ by HTL clones K22 (DR1/15, DQ5/6 donor), clone 5 (DR4/9, DQ7/8 donor) and Sa24 (DR4/15, DQ1/4 donor) as the result of stimulation with peptide Aurora-A233–247. In all instances, autologous irradiated PBMCs were used as APCs. Points means of triplicate determinations, bars SD. Points without bars had SD < 10% the value of the mean. Results are representative of two experiments that were done with the same samples