Fig. 2.

Suppression of tumor growth and prolonged survival by administration of pcDNA-sTGFβR/huIg in tumor-bearing mice. The C57BL/6 mice were inoculated with 2×10⁵ EL4 or E.G7 cells. The mice were injected with 30 μg of pcDNA-sTGFβR/huIg (sTGFR) or control pcDNA3.1 (mock) through different routes 10–12 days after tumor inoculation. The DNA injection was repeated every other week. The sizes of the tumors were monitored twice a week. The EG.7-bearing mice received pcDNA-sTGFβR/huIg intraperitonieally (ip) (a; n=6), intramuscularly (im) (b; n=5) or intratumorally (it) (c; n=7). Control pcDNA3.1 was inoculated intraperitonieally (d; n=6) or intratumorally (e; n=7). The EL4-bearing mice received pcDNA-sTGFβR/huIg intraperitonieally (f; n=5) or intratumorally (g; n=5). Kaplan–Meier curves were generated for survival time of the mice (h). Experiments were repeated three times and the results are representative of the experiments. *P<0.004