Fig. 5.

Biodistribution of multivalent scFvs in xenografted mice. a Biodistribution of ¹¹¹In-labeled scFv(1aa) (triabody) after 24 h. b Biodistribution of ¹¹¹In-labeled scFv(0aa) (tetrabody) after 24 h. Specific activity was ∼1 μCi/μg protein. Se serum, Tu tumor, Br brain, Bo bone marrow, He heart, Lu lung, Li liver, Sp spleen, Ki kidney. Means from groups of four mice each are expressed as % ID/g. cAmount of ¹¹¹In-labeled scFv(1aa) (dotted line) and scFv(0aa) (solid line) in the serum of xenografted mice over time