Fig. 4.

Therapeutic effects of vaccination with pIL-18 and pAPOPTIN. Seven days after tumor inoculation, C57BL/6 mice bearing established LLC tumors were treated with the pIL-18 and pAPOPTIN plasmid therapies. a Tumor growth was measured as the product (a × b) of the maximal diameter (a) and the perpendicular diameter (b). Bars represent the standard deviation of tumor size with five mice per group. Each data point represents the mean tumor size ± SD. This experiment was performed twice and essentially identical results were obtained. b Survival of mice in the respective treatment groups. Mice surviving at the last follow-up were tumor-free unless otherwise noted. This experiment was performed twice and essentially identical results were obtained