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. 2023 Oct 30;2(11):1015–1031. doi: 10.1038/s44161-023-00354-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — a) Trajectory analysis revealed stages of differentiation following monocyte entry associated with inflammatory macrophage clusters. b) Upregulation of inflammation genes associated with entry into intima and commitment toward inflammatory macrophage differentiation. c) Ccl3 and Ccl4 were uniquely expressed by committed inflammatory cells, but not by intermediate inflammatory cells. d) MHC-II expression is gradually elevated along commitment toward inflammatory differentiation arm of the trajectory map. e) Cd47 and Sirpa expression on trajectory map.