Table 2.
Comparison of clinicopathological characteristics of follicular thyroid cancer in various clinical settings
| Variable | Level | Comparison 1 | Comparison 2 | Comparison 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| TC-BC | TCnoBC | P | TC-1st | TCnoBC | P | BC-1st | TCnoBC | P | ||
| n | 604 | 3020 | 314 | 1570 | 290 | 1450 | ||||
| Age, y (median [IQR]) | 61.00 (50.00-71.00) |
61.00 (50.00-70.00) |
.743 | 55.00 (45.00-66.00) |
55.00 (45.00-66.00) |
.848 | 67.00 (57.00-74.00) |
66.00 (57.00-74.00) |
.764 | |
| Race (%) | White | 490 (81.1) | 2362 (78.2) | .267 | 250 (79.6) | 1217 (77.5) | .7 | 240 (82.8) | 1157 (79.8) | .4801 |
| Black | 55 (9.1) | 328 (10.9) | 29 (9.2) | 165 (10.5) | 26 (9.0) | 144 (9.9) | ||||
| Other | 59 (9.7) | 330 (10.9) | 35 (11.1) | 188 (11.9) | 24 (8.2) | 149 (10.3) | ||||
| Pathological subtype (%) | FA | 309 (51.2) | 1545 (51.2) | .6 | 176 (56.1) | 876 (55.8) | .169 | 133 (45.9) | 678 (46.8) | .94 |
| OX | 191 (31.6) | 977 (32.4) | 86 (27.4) | 473 (30.1) | 105 (36.2) | 509 (35.1) | ||||
| FAMI | 70 (11.6) | 334 (11.1) | 28 (8.9) | 124 (7.9) | 42 (14.5) | 204 (14.1) | ||||
| FAT | 10 (1.7) | 29 (1.0) | 9 (2.9) | 18 (1.1) | 1 (0.3) | 11 (0.8) | ||||
| FAWD | 24 (4.0) | 135 (4.5) | 15 (4.8) | 79 (5.0) | 9 (3.1) | 48 (3.3) | ||||
| Stage (%) | Localized | 437 (72.4) | 2083 (69.0) | .04c | 217 (69.1) | 1000 (63.7) | .043c | 220 (75.9) | 1073 (74.0) | .398 |
| Regional | 130 (21.5) | 658 (21.8) | 83 (26.4) | 441 (28.1) | 47 (16.2) | 224 (15.4) | ||||
| Distant | 37 (6.1) | 279 (9.2) | 14 (4.5) | 129 (8.2) | 23 (7.9) | 153 (10.6) | ||||
| Tumor size, cm (%) | <1 | 38 (6.3) | 151 (5.0) | <.001a | 22 (7.0) | 87 (5.5) | .087d | 16 (5.5) | 62 (4.3) | <.001a |
| 1-2 | 178 (29.5) | 674 (22.3) | 90 (28.7) | 370 (23.6) | 88 (30.3) | 294 (20.3) | ||||
| 2-4 | 244 (40.4) | 1353 (44.8) | 123 (39.2) | 724 (46.1) | 121 (41.7) | 634 (43.7) | ||||
| >4 | 144 (23.8) | 842 (27.9) | 79 (25.2) | 389 (24.8) | 65 (22.4) | 460 (31.7) | ||||
| Extension (%) | Localized | 515 (85.3) | 2501 (82.8) | .036c | 278 (88.5) | 1319 (84.0) | .024c | 237 (81.7) | 1181 (81.4) | .626 |
| Beyond capsule | 73 (12.1) | 366 (12.1) | 31 (9.9) | 175 (11.1) | 42 (14.5) | 196 (13.5) | ||||
| Further | 16 (2.6) | 153 (5.1) | 5 (1.6) | 76 (4.8) | 11 (3.8) | 73 (5.0) | ||||
| LN Met (%) | Yes | 32 (5.3) | 209 (6.9) | .17 | 15 (4.8) | 109 (6.9) | .198 | 17 (5.9) | 106 (7.3) | .451 |
| No | 572 (94.7) | 2811 (93.1) | 299 (95.2) | 1461 (93.1) | 273 (94.1) | 1344 (92.7) | ||||
| Dis Met (%) | Yes | 37 (6.1) | 276 (9.1) | .02c | 14 (4.5) | 127 (8.1) | .034c | 23 (7.9) | 152 (10.5) | .226 |
| No | 567 (93.9) | 2744 (90.9) | 300 (95.5) | 1443 (91.9) | 267 (92.1) | 1298 (89.5) | ||||
| Multifocal (%) | Yes | 66 (18.4) | 287 (16.0) | .534 | 24 (18.9) | 97 (6.2) | .595 | 42 (14.5) | 190 (13.1) | .813 |
| No | 292 (81.6) | 1503 (84.0) | 103 (81.1) | 538 (34.3) | 189 (65.2) | 965 (66.6) | ||||
| TC-specific mortality (%) | Yes | 35 (5.8) | 255 (8.4) | .035c | 13 (4.1) | 130 (8.3) | .016c | 22 (7.6) | 122 (8.4) | .726 |
| No | 569 (94.2) | 2765 (91.6) | 301 (95.9) | 1440 (91.7) | 268 (92.4) | 1328 (91.6) | ||||
| Marital status (%) | Married | 352 (58.3) | 1759 (58.2) | ≥.999 | 191 (60.8) | 982 (62.5) | .61 | 161 (55.5) | 789 (54.4) | .78 |
| Unmarried | 252 (41.7) | 1261 (41.8) | 123 (39.2) | 588 (37.5) | 129 (44.5) | 661 (45.6) | ||||
| Insurance (%) | Yes | 269 (44.5) | 1332 (44.1) | 72 (22.9) | 360 (22.9) | 197 (67.9) | 974 (67.2) | |||
| No | 3 (0.5) | 28 (0.9) | .574 | 2 (0.6) | 10 (0.6) | ≥.999 | 1 (0.3) | 16 (1.1) | .486 | |
| Not 2007+ | 332 (55.0) | 1660 (55.0) | 240 (76.4) | 1200 (76.4) | 92 (31.7) | 460 (31.7) | ||||
| Education (median [IQR]) | 83.55 (79.18-88.68) |
84.36 (79.46-88.42) |
.217 | 83.55 (78.36-86.43) |
83.55 (79.46-87.52) |
.032c | 85.40 (79.21-89.65) |
86.00 (80.27-89.27) |
.746 | |
| Income (median [IQR]) | 5525.00 (4227.00-6102.00) |
5548.00 (4244.00-6191.75) |
.315 | 5087.00 (4219.00-5683.98) |
5316.00 (4219.00-5829.00) |
.248 | 5607.50 (4555.25-6387.50) |
5620.00 (4586.25-6799.50) |
.363 | |
| Unemployment (median [IQR]) | 7.75 (5.69-8.70) | 7.68 (5.59-8.70) | .972 | 7.53 (5.30-8.23) | 7.39 (5.25-8.23) | .834 | 7.80 (5.94-9.60) | 7.80 (6.03-9.53) | .875 | |
Abbreviations: BC, breast cancer; BC-1st, TC patients diagnosed after BC; Dis, distant; FA, follicular adenocarcinoma, NOS; FAT, FA trabecular; FAWD, FA well differentiated; IQR, interquartile range; LN, lymph node; Met, metastases; OX, oxyphilic adenocarcinoma; TC, thyroid cancer; TC-1st, TC patients diagnosed before BC; TCnoBC, TC patients without history of BC.
a P less than .001; bP less than .01; cP less than .05; dP less than .1.