. 2023 Dec 8;109(5):1222–1230. doi: 10.1210/clinem/dgad722

Table 3.

Effects of history of breast cancer on thyroid cancer-specific mortality in Cox regression models

Comparison		Univariable model			Multivariable model^e			Multivariable model^f
Comparison		HR	95% CI	P	HR	95% CI	P	HR	95% CI	P
PTC	TC-BC vs TCnoBC	0.472	0.370-0.601	<.001^a	0.477	0.375-0.608	<.001^a	0.529	0.415-0.675	<.001^a
	TC-1st vs TCnoBC	0.397	0.268-0.588	<.001^a	0.399	0.270-0.591	<.001^a	0.409	0.276-0.607	<.001^a
	BC-1st vs TCnoBC	0.607	0.445-0.827	.002^b	0.625	0.458-0.852	<.001^b	0.797	0.584-1.088	.153
FTC	TC-BC vs TCnoBC	0.656	0.461-0.934	.019^c	0.648	0.455-0.922	.016^c	0.799	0.560-1.140	.215
	TC-1st vs TCnoBC	0.458	0.259-0.810	.007^b	0.448	0.253-0.792	.006^b	0.568	0.319-1.011	.054^d
	BC-1st vs TCnoBC	0.926	0.588-1.459	.741	0.940	0.597-1.480	.789	1.262	0.795-2.003	.324

Abbreviations: BC, breast cancer; BC-1st, TC patients diagnosed after BC; CI, confidence interval; FTC, follicular TC; HR, hazard ratio; PTC, papillary TC; SEER, Surveillance, Epidemiology and End Results; SES, socioeconomic status; TC, thyroid cancer; TC-1st, TC patients diagnosed before BC; TCnoBC, TC patients without history of BC.

^aP less than .001; ^bP less than .01; ^cP less than .05; ^dP less than .1.

^eMultivariable model adjusted by SES factors including race, medical insurance, education levels.

^fMultivariable model adjusted by SES factors including race, medical insurance, and education levels and clinicopathological characteristics including SEER stage, tumor size, and distant metastasis and extension.