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. 2023 Dec 8;109(5):1222–1230. doi: 10.1210/clinem/dgad722

Table 3.

Effects of history of breast cancer on thyroid cancer-specific mortality in Cox regression models

Comparison Univariable model Multivariable modele Multivariable modelf
HR 95% CI P HR 95% CI P HR 95% CI P
PTC TC-BC vs TCnoBC 0.472 0.370-0.601 <.001a 0.477 0.375-0.608 <.001a 0.529 0.415-0.675 <.001a
TC-1st vs TCnoBC 0.397 0.268-0.588 <.001a 0.399 0.270-0.591 <.001a 0.409 0.276-0.607 <.001a
BC-1st vs TCnoBC 0.607 0.445-0.827 .002b 0.625 0.458-0.852 <.001b 0.797 0.584-1.088 .153
FTC TC-BC vs TCnoBC 0.656 0.461-0.934 .019c 0.648 0.455-0.922 .016c 0.799 0.560-1.140 .215
TC-1st vs TCnoBC 0.458 0.259-0.810 .007b 0.448 0.253-0.792 .006b 0.568 0.319-1.011 .054d
BC-1st vs TCnoBC 0.926 0.588-1.459 .741 0.940 0.597-1.480 .789 1.262 0.795-2.003 .324

Abbreviations: BC, breast cancer; BC-1st, TC patients diagnosed after BC; CI, confidence interval; FTC, follicular TC; HR, hazard ratio; PTC, papillary TC; SEER, Surveillance, Epidemiology and End Results; SES, socioeconomic status; TC, thyroid cancer; TC-1st, TC patients diagnosed before BC; TCnoBC, TC patients without history of BC.

aP less than .001; bP less than .01; cP less than .05; dP less than .1.

e Multivariable model adjusted by SES factors including race, medical insurance, education levels.

f Multivariable model adjusted by SES factors including race, medical insurance, and education levels and clinicopathological characteristics including SEER stage, tumor size, and distant metastasis and extension.