Table 2.

LASSO selected predictors of the risk of 12-month transient cognitive decline among older women with breast cancer^a

Model with baseline APE domain scoreb		Model without baseline APE domain scoref
Variable	Odds ratio a	Variable	Odds ratio a
Treatment type—chemoc	0.99	Treatment type—chemo	0.98
Cardiovascular disease comorbidity	1.64	Cardiovascular disease comorbidity	1.56
BMI >30d	2.07e	BMI >30	1.96
ApoE4 positivity (vs E4 negative)	3.60	ApoE4 positivity (vs E4 negative)	3.51
Number of prescription drugs regularly taken, per one drug	1.12	Number of prescription drugs regularly taken, per one drug	1.10
HER2 positivity (vs negative)	0.19	HER2 positivity (vs negative)	0.25
Baseline APE domain z-score	2.35	Baseline APE domain score	—

^aLogistic regression model with least absolute shrinkage and selection operator (LASSO) was used to identify predictors indicative of risk of cognitive decline. Fourfold cross-validation was used during the model optimization of tuning and penalty parameters to obtain the model selected variables and corresponding regression coefficient estimates for the displayed LASSO model outputs. Regression coefficients are summarized using odds ratios (OR) of being decliners in LASSO logistic regression. The model output in the left panel corresponds to an area under the curve (AUC) of 0.750, while the model without a measure of baseline cognitive reserve (APE domain score) corresponds to an AUC of 0.710.

^bThe APE domain is a summary Z-score of performance on six neuropsychologic tests of Attention, Processing speed, and Executive function.

^cSystemic treatment categories are for chemotherapy with or without endocrine therapy vs the referent group of endocrine therapy alone.

^dBMI = weight (kg)/height (m²) at baseline.

^eExample interpretation: For a cancer survivor, moving from the category BMI <30 to the category BMI > 30, the odds of cognitive decline increase by 2.069 times, more than doubling the odds of cognitive decline.

^fMMSE, WRAT-4, years of education as a substitute measure of baseline cognitive reserves.