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. 2024 Apr 1;8(2):pkae019. doi: 10.1093/jncics/pkae019

Table 4.

LASSO model prediction for cognitive decline under varying scenarios

Scenarioa Treatment typeb ApoE4 positivity Cardiovascular disease comorbidityc BMI ≥30 Number of prescription drugs regularly takend HER2 Positivity Baseline APE domain score IPAQ daily sedentary timef SF12 Mental Component Scoreg Probability of transient decline (95% CI)e Probability of persistent decline (95% CI)
a Chemo No No No 2 No 0.30 8 57

  • 0.19

  • (0.09 to 0.34)

  • 0.05

  • (0.02 to 0.13)
b Chemo Yes No No 2 No 0.30 8 57

  • 0.45

  • (0.25 to 0.68)

  • 0.11

  • (0.032 to 0.30)
c Chemo Yes Yes No 2 No 0.30 8 57

  • 0.57

  • (0.35 to 0.78)

  • 0.14

  • (0.04 to 0.36)
d Chemo Yes Yes Yes 2 No 0.30 8 57

  • 0.74

  • (0.49 to 0.89)

  • 0.26

  • (0.09 to 0.56)
e Chemo Yes Yes Yes 5 No 0.30 8 57

  • 0.80

  • (0.60 to 0.92)

  • 0.45

  • (0.20 to 0.73)
f Chemo Yes Yes Yes 5 Yes 0.30 8 57

  • 0.43

  • (0.11 to 0.88)

  • 0.32

  • (0.06 to 0.78)
g Chemo Yes Yes Yes 5 Yes 0.30 14 57

  • 0.15

  • (0.02 to 0.63)
h Chemo Yes Yes Yes 5 Yes 0.30 14 40

  • 0.65

  • (0.10 to 0.97)
a

Scenario represents an actual survivor risk profile from our analytical sample. The prediction probabilities using our LASSO model for transient 12-month and persistent 24-month cognitive declines, and their corresponding 95% CIs are shown. The top row represents this survivor’s actual profile, following rows illustrate the effects of this survivor’s risk of cognitive decline if her profile is modified. Risk factors changes from scenario a are noted in bold text in the table.

b

Systemic treatment categories are for chemotherapy with or without endocrine therapy vs the referent group of endocrine therapy alone.

c

Includes angina, arrhythmia, hypertension, heart attack, peripheral vascular disease, and other cardiovascular disease.

d

Includes statins, medication for mood or nerves, blood pressure medication, pain medication, over-the-counter medications, multivitamins, and other prescription medications.

e

LASSO does not select IPAQ daily sedentary time and SF12 Mental Component score for transient declines; probabilities of transient decline for scenarios g and h are not considered.

f

IPAQ = International Physical Activity Questionnaire.

g

The SF12 questionnaire is a health-related quality-of-life questionnaire consisting of twelve questions that measure eight health domains to assess physical and mental health. The mental health-related component includes Vitality, Social Functioning, Role Emotional, and Mental Health scales.