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. Author manuscript; available in PMC: 2025 Apr 1.
Published in final edited form as: Lab Invest. 2024 Jan 28;104(4):102025. doi: 10.1016/j.labinv.2024.102025

Figure. 1. Stress-induced increase in the levels of growth differentiation factor-15 in human trabecular meshwork cells.

Figure. 1.

Human trabecular meshwork (TM) cells treated with agents inducing senescence (20 μM BIBR1532, telomerase inhibitor for 24 h, ER stress (1 μg/ml Tunicamycin, 48 h), oxidative stress (200 μM H2O2, 3 h) and autophagy inhibitor (2 μM IITZ-01, 6 h) significantly (** P<0.001) elevated the levels of growth differentiation factor-15 (GDF15) compared to control cells based on immunoblot analysis. N=5 to 6.