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. Author manuscript; available in PMC: 2025 Apr 1.
Published in final edited form as: Lab Invest. 2024 Jan 28;104(4):102025. doi: 10.1016/j.labinv.2024.102025

Figure. 2. Upregulation of expression of genes encoding extracellular matrix proteins and other proteins in human TM cells treated with recombinant human GDF15.

Figure. 2.

Serum starved human TM cells (three strains; n=3) treated with rh human GDF15 (20 ng/ml for 48 h) are evaluated for differential gene expression based on RNAseq analysis. A). Heat map of expression values of differentially expressed genes in rh GDF15 treated TM cells compared to control TM cells. Only differentially expressed genes (≥ 1.5 fold difference in expression, adjusted P value of ≤ 0.05) were used for creating the heat map. Three individual TM cell strains (treated and control, side by side columns) are shown. Each box within each column represents the expression of indicated gene. The genes are hierarchically clustered using a correlation distance with complete linkage and show the similarity of their expression profiles between rh GDF15 treated and control TM cells. B). The volcano plot depicting the results of the comparison between rhGDF15 treated and control TM cells. The log2-fold changes which were calculated based on rhGDF15 treated/control were plotted on the x-axis. The – log10 p-values are plotted on the y axis. Each dot represents a gene.