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. Author manuscript; available in PMC: 2025 Apr 1.
Published in final edited form as: Lab Invest. 2024 Jan 28;104(4):102025. doi: 10.1016/j.labinv.2024.102025

Figure 5. Decreased aqueous humor outflow facility in recombinant human GDF15 perfused enucleated mouse eyes.

Figure 5.

A). To test whether GDF15 influences aqueous humor (AH) outflow facility, enucleated eyes derived from the 8 to 9 month-old (male and female) mice were perfused with rh GDF15 (4 ng/ml) and determined AH outflow facility in comparison with vehicle perfused control eyes (contralateral) as described in the Methods section. The AH outflow facility (nl/min/mmHg) in rh GDF15 perfused eyes (n=12) was found to be significantly (*P<0.01; by ~30%) decreased compared to vehicle perfused contralateral eyes (n=12). B). Light microscope-based histological examination of the conventional AH outflow pathway showed a similar morphology integrity between the GDF15 perfused and vehicle perfused eyes. TM; trabecular meshwork, SC; Schlemm’s canal. Bar indicates image magnification.