Table 1.
Lead sleep apnea and insomnia local genetic heritability regions.
| Phenotype | Chromosome | Start | End | h2g p- value |
Protein-coding Genes in Region |
|---|---|---|---|---|---|
| Sleep apnea | 5 | 81,174,678 | 82,414,318 | 1.86 × 10−11 | ACOT12, ATG10, CKMT2, RASGRF2, RPS23, SSBP2, ZCCHC9 |
| Sleep apnea | 3 | 168,549,584 | 169,880,814 | 2.67 × 10−6 | ACTRT3, LRRC31, LRRC34, LRRIQ4, MECOM, MYNN |
| Sleep apnea | 6 | 27,518,868 | 28,703,605 | 3.58 × 10−5 | GPX5, GPX6, H1-5, H2AC13, H2AC14, H2AC15, H2AC16, H2AC17, H2BC13, H2BC14, H2BC15, H2BC17, H3C10, H3C11, H3C12, H4C11, H4C12, H4C13, NKAPL, OR2B2, OR2B6, OR2B8P, PGBD1, ZBED9, ZKSCAN3, ZKSCAN4, ZKSCAN8, ZKSCAN8P1, ZNF165, ZSCAN12, ZSCAN16, ZSCAN23, ZSCAN26, ZSCAN31, ZSCAN9 |
| Sleep apnea | 8 | 85,490,346 | 86,552,020 | 1.36 × 10−4 | ATP6V0D2, CPNE3, PSKH2, RMDN1, SLC7A13, WWP1 |
| Sleep apnea | 6 | 11,217,931 | 11,775,181 | 2.36 × 10−4 | ADTRP, NEDD9, TMEM170B |
| Sleep apnea | 9 | 104,298,903 | 105,440,109 | 2.76 × 10−4 | ABCA1, NIPSNAP3A, NIPSNAP3B, OR13C2, OR13C3, OR13C4, OR13C5, OR13C8, OR13C9, OR13D1, OR13F1, SLC44A1 |
| Sleep apnea | 8 | 9,979,082 | 10,620,638 | 2.79 × 10−4 | MSRA, PRSS51, PRSS55, RP1L1 |
| Sleep apnea | 8 | 66,215,247 | 67,662,602 | 3.06 × 10−4 | ADHFE1, ARFGEF1, C8orf44-SGK3, COPS5, CPA6, CSPP1, MCMDC2, MYBL1, PPP1R42, RRS1, SGK3, TCF24, VCPIP1, VXN |
| Sleep apnea | 12 | 4,858,524 | 5,775,562 | 4.50 × 10−4 | ANO2, KCNA1, KCNA5, NTF3 |
| Sleep apnea | 1 | 158,930,438 | 159,762,876 | 8.92 × 10−4 | ACKR1, AIM2, APCS, CADM3, CRP, FCER1A, IFI16, OR10J1, OR10J3, OR10J4, OR10J5, PYDC5, PYHIN1 |
| Insomnia | 10 | 102,437,650 | 103,700,556 | 3.71 × 10−5 | ACTR1A, ARL3, AS3MT, ATP5MK, BORCS7, BORCS7-ASMT, C10orf95, CALHM1, CALHM2, CALHM3, CNNM2, CYP17A1, INA, MFSD13A, NEURL1, NT5C2, PCGF6, PDCD11, RPEL1, SFXN2, SH3PXD2A, SUFU, TAF5, TRIM8, WBP1L |
| Insomnia | 9 | 94,710,721 | 95,785,833 | 4.02 × 10−5 | AOPEP, FANCC, PTCH1 |
| Insomnia | 2 | 1,377,422 | 1,991,457 | 4.73 × 10−5 | MYT1L, PXDN, TPO |
| Insomnia | 2 | 51,442,356 | 52,267,286 | 1.26 × 10−4 | |
| Insomnia | 11 | 11,337,460 | 12,128,955 | 1.65 × 10−4 | CSNK2A3, DKK3, GALNT18, MICAL2, USP47 |
| Insomnia | 4 | 148,808,693 | 149,733,447 | 1.88 × 10−4 | IQCM |
| Insomnia | 8 | 18,428,040 | 19,106,735 | 2.02 × 10−4 | PSD3 |
| Insomnia | 14 | 65,832,798 | 66,559,780 | 2.76 × 10−4 | CCDC196, GPHN |
| Insomnia | 7 | 128,263,781 | 129,144,853 | 7.51 × 10−4 | ATP6V1F, ATP6V1FNB, CALU, CCDC136, FLNC, GARIN1A, GARIN1B, HILPDA, IMPDH1, IRF5, KCP, METTL2B, OPN1SW, PRRT4, RBM28, TNPO3, TSPAN33 |
| Insomnia | 1 | 58,073,339 | 58,847,823 | 8.69 × 10−4 | DAB1, JUN, MYSM1, OMA1, TACSTD2 |
All calculations adjusted for age, sex, body mass index, and 10 population principal components. Region borders were calculated by LAVA [22] using the Mass General Brigham data with Build 38 coordinates. Full results for nominally significant regions are provided in Table S3. h2g: single nucleotide variant-based heritability.