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The Nef-targeting moiety (red, upper left) provides two positions on the phenyl rings for linker attachment (x and y). CRBN ligands included analogs of thalidomide (green, center) and lenalidomide (blue, right) that were attached to the isoindoline ring at positions 4 and 5. Linker compositions are shown below adjacent to each analog number. The complete structure of FC-14367 is also provided.
