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. Author manuscript; available in PMC: 2025 Apr 17.
Published in final edited form as: Neuron. 2024 Feb 14;112(8):1286–1301.e8. doi: 10.1016/j.neuron.2024.01.018

Figure 7. ASIC channels are required for whisker tactile discrimination.

Figure 7.

A) Schematic illustration of the whisker tactile discrimination test, which consists of a tactile familiarization phase (left) with two identical smooth-surface-objects (S1 and S2) and a tactile discrimination phase with S1 and a rough-surface-object (R) (right). B) Time of palpation of S1 and S2 objects during the tactile familiarization phase in the control group, amiloride-treated group, and diminazene-treated group. C) Time of palpation of S1 and R objects during the tactile discrimination phase in the control group, amiloride-treated group, and diminazene-treated group. D) Preference index of control, amiloride-treated, and diminazene-treated groups. The dose of amiloride was 5 mg/kg and diminazene was 2.5 mg/kg. E) Time of palpation of S1 and S2 objects during the tactile familiarization phase in ASIC3+/+ mice and ASIC3−/− mice. F) Time of palpation of S1 and R objects during the tactile discrimination phase in ASIC3+/+ mice and ASIC3−/− mice. G) Preference index of ASIC3+/+ mice and ASIC3−/− mice. Data represent independent observations and mean ± SEM, *p < 0.05, ns, not significantly different, one-way ANOVE with Bonferroni or Dunnett’s post hoc tests. See also Figure S8.