Table 2:
Pathways analysis per periods
| Periods | Term | Combined Score |
|---|---|---|
| 0am – 8am | regulation of glial cell apoptotic process (GO:0034350) | 1092.6 |
| negative regulation of glial cell apoptotic process (GO:0034351) | 837.4 | |
| positive regulation of mast cell chemotaxis (GO:0060754) | 648.5 | |
| regulation of mast cell chemotaxis (GO:0060753) | 460.2 | |
| lymphocyte mediated immunity (GO:0002449) | 460.2 | |
| 8am – 2pm | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway (GO:0070426) | 2185.5 |
| cellular heat acclimation (GO:0070370) | 1568.4 | |
| regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (GO:0070432) | 1568.4 | |
| heat acclimation (GO:0010286) | 1568.4 | |
| positive regulation of microtubule nucleation (GO:0090063) | 1207.9 | |
| 2pm–8pm | actin filament depolymerization (GO:0030042) | 802.3 |
| regulation of glomerular mesangial cell proliferation (GO:0072124) | 504.4 | |
| regulation of plasma membrane organization (GO:1903729) | 504.4 | |
| Cytosolic tRNA Aminoacylation R-HSA-379716 | 369.2 | |
| regulation of immature T cell proliferation in thymus (GO:0033084) | 356.9 | |
| 8pm–0am | regulation of growth hormone receptor signaling pathway (GO:0060398) | 293.8 |
| positive regulation of smooth muscle cell differentiation (GO:0051152) | 293.8 | |
| membrane raft distribution (GO:0031580) | 293.8 | |
| determination of left/right asymmetry in lateral mesoderm (GO:0003140) | 293.8 | |
| positive thymic T cell selection (GO:0045059) | 293.8 |
Notes: Using the peaking circadian proteins and GO_Biological_Process_2021, Reactome_2022, KEGG_2021_Human databases, we present the most significant pathways in the given periods segments of the 24-hour day.