Figure 1. Study design and resource generation.

(A) Schematic depicting experimental design and bioinformatics pipeline of the study. (B) Uniform manifold approximation and projection of scATAC cells (left) labeled using matched scRNA cells (right) labeled using a CITE-Seq atlas. (C) Scan QR code to view interactive ShinyCell application hosting RNA and TCR datasets. (D) Schematic portraying study approach; methods include analysis of disease status and the effects on APOE genotype-associated epigenomes and transcriptomes (top) and analysis between APOE genotypes and effects on disease-associated epigenomes and transcriptomes (bottom).