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. Author manuscript; available in PMC: 2025 Apr 17.
Published in final edited form as: Neuron. 2024 Feb 9;112(8):1235–1248.e5. doi: 10.1016/j.neuron.2024.01.013

Figure 4. Cis-regulatory sequence correlates with quantity of transcription of CXCR3 in CD8 T cells, which home to the AD brain.

Figure 4.

(A) Number of gene promoter to region connections filtered for only significant correlations with corresponding gene expression [> 95th % of Pearson correlation coefficient (PCC) per cell type; P-adjusted<0.05]. (B) Overlap of significant promoter-region correlations with AD vs HC DEGs in CD8 TEM cells. (C) Representative Cicero CXCR3 promoter-region connections (bottom; HC in gray, AD in red). CXCR3 distal region accessibility (CD8 T cells) to gene expression (CD8 TEM cells) correlation in AD samples (top). (D) CXCR3-expressing CD8 T cells in post-mortem AD hippocampus. Arrowheads indicate CXCR3+CD3+CD8+ T cells. Scale bar=15 μm. (E) CXCR3+CD3+CD8+ T cells in post-mortem AD leptomeninges. Scale bar=20 μm. (F) A CD3+ T cell interacting with an Aβ plaque-associated Iba1+ microglial cell. Scale bar=10 μm.