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. Author manuscript; available in PMC: 2025 Apr 17.
Published in final edited form as: Neuron. 2024 Feb 9;112(8):1235–1248.e5. doi: 10.1016/j.neuron.2024.01.013

Figure 6. Epigenetic dysregulation of AD risk genes in the peripheral immune system.

Figure 6.

(A) Heatmap depicting number of DARs in AD risk genes by cell type comparing AD vs. HC. (B) Heatmap depicting number of DARs in AD risk genes by cell type comparing AD vs. HC APOE ε4/ε4 carriers (n = 7 HC APOE ε4/ε4, 8 AD APOE ε4/ε4). (C) Chromatin track of ABCA1 showing locations of significant DARs in various peripheral immune cell types of AD vs. HC APOE ε4/ε4 carriers (n = 7 HC APOE ε4/ε4, 8 AD APOE ε4/ε4). (D) Chromatin track of BIN1 showing locations of significant DARs in various peripheral immune cell types of AD vs. HC APOE ε4/ε4 carriers (n = 7 HC APOE ε4/ε4, 8 AD APOE ε4/ε4). (E) Chromatin track of BIN1 showing the significant DARs in CD8 T cells of AD vs. HC APOE ε4/ε4 carriers (n = 7 HC APOE ε4/ε4, 8 AD APOE ε4/ε4). (F) Uniform manifold approximation and projection plot of clonal and non-clonal T cells from scTCRseq analysis of scRNAseq data. (G) Volcano plot showing BIN1 upregulation in clonal CD8 TEM cells in AD vs. HC APOE ε4/ε4 carriers [n = 7 HC APOE ε4/ε4, 8 AD APOE ε4/ε4. HC APOE ε4/ε4 clonal CD8 TEMs = 4019, median (IQR) = 652.5 (485.75 – 942.25), AD APOE ε4/ε4 clonal CD8 TEMs = 7120, median (IQR) = 526.5 (185.25 – 1264.25)].