Table 2:

Jesinghaus grading system

Grade	Number of buds*	Size of buds	Novel grade score**
1	0	>15 tumor cells (large)	2–3 score: grade 1 (G1, well differentiated)
2	1–14	5–15 tumor cells (intermediate)	4–5 score: grade 2 (G2, moderately differentiated)
3	>15	2–4 tumor cells (small)	6–7 score: grade 3 (G3, poorly differentiated)
4	-	single tumor cell detached within the stroma

^*The number of buds are determined in the highest budding activity (hotspot), in 10 high-power fields (HPFs)

^**The sum of tumor budding and cell cluster size score generates a final grading score ranging from 2 to 7