Fig. 4. Male and female SMA-affected pups exhibit similar righting ability.

Righting reflex times, in seconds (s), at 2-day intervals starting at P6 until P16 are not significantly different when a) including failed trials (>60s task time) and b) excluding failed trials. Multiple unpaired Student’s t-tests with Šídák-Bonferroni method of correction for multiple comparisons. c) Failure rate as a percentage, for male (blue) and female (red) SMA pups at 2-day intervals from P6 to P16 are not significantly different. Fisher’s exact contingency tests to statistically compare proportions. Biological and technical replicate sizes are shown in Table 3.