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. Author manuscript; available in PMC: 2025 May 1.
Published in final edited form as: Am J Ophthalmol. 2024 Feb 3;261:141–164. doi: 10.1016/j.ajo.2024.01.023

Figure 3. OCT-detected exposed neural canal (ENC) morphology (A) includes externally oblique choroidal border tissue (EOCBT) and/or exposed scleral flange (ESF) (B, C and D) regions.

Figure 3.

(A) Pre-scleral and scleral flange neural canal anatomy projected onto the fundus photo of study eye Hi-Myo-GL-29, (also shown in Figure 1). Here the OCT ENC region is longest temporally, and extends from Bruch’s membrane opening (BMO–red dots) to the scleral flange opening (SFO-yellow dots). OCT landmarks are shown relative to the Foveal-to-BMO centroid (FoBMO) axis and 12 FoBMO 30° sectors (sectoral acronyms defined below). (B) Here the EOCBT region (BMO peripheral to the ASCO) is shown in translucent green), and the adjacent crescent of ESF is shown in translucent magenta (also on the left of Panel D). (C) OCT-radial B-scan from the location depicted by the green line in Panel B. (D) The scleral flange histologically refers to the region of the pNC-sclera that is internal to the insertion of the dural sheath.23–26 Because, the dural sheath is not consistently visualized in OCT B-scans, the outer boundary of the scleral flange can not (yet) be consistently determined by OCT. We hypothesize that EOCBT and ESF regions are a manifestation of neural canal remodeling that is required when BMO enlarges and/or shifts temporally relative to the ASCO and SFO (when present). IOCBT - internally oblique choroidal border tissues (BMO central to the ASCO) (right side of Panel C); FoBMO 30° sectoral acronyms (Panel A): S-superior; SN-superior-nasal; NS-nasal-superior; N-nasal; NI-nasal-inferior; IN-inferior-nasal; I-Inferior; IT-Inferior-temporal; TI-temporal-inferior; T-temporal; TS-temporal-superior; ST-superior-temporal.