Table 1.
Demographic and Ocular Characteristics of the Study Participants and Non-Highly Myopic Healthy (Non-Hi-Myo-Healthy) versus Highly Myopic (Hi-Myo) Eyes.
| Non-Hi-Myo-Healthy Eyes (n=362) | Hi-Myo Eyes (n=122) | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| All Eyes (n=362) | Non-Hi-ESF Eyes (n=289) | Hi-ESF Eyes (n=73) | All Eyes (n=122) | Non-Hi-ESF Eyes (n=35) | Hi-ESF Eyes (n=87) | |
| Female Gender (n (%)) | 202 (55.8) | 165 (57.1) | 37 (50.7) | 58 (47.5) | 17 (48.6) | 41 (47.1) |
| Left Eye (n (%)) | 181 (50.0) | 147 (50.9) | 34 (46.6) | 58 (47.5) | 17 (48.6) | 41 (47.1) |
| Age (year ± SD, (range)) | 50.6 ± 17.5 (19.8 to 90.3) | 50.3 ± 17.7 (19.8 to 90.3) | 52.0 ± 16.9 (20.3 to 84.3) | 58.6 ± 15.0*** (26.0 to 87.8) | 56.8 ± 17.1 (26.0 to 84.1) | 59.4 ± 14.1** (27.0 to 87.8) |
| Axial Length (mm ± SD, (range)) | 23.74 ± 0.95 (21.41 to 26.44) | 23.64 ± 0.88 (21.41 to 26.44) | 24.15 ± 1.11††† (21.96 to 26.29) | 26.98 ± 1.00*** (24.84 to 30.74) | 26.97 ± 1.04*** (24.84 to 29.74) | 26.98 ± 0.99*** (24.86 to 30.74) |
| Spherical Equivalent (diopter ± SD, (range)) | −0.47 ± 1.82 (−6.00 to 5.375) | −0.24 ± 1.53 (−5.75 to 5.375) | −1.38 ± 2.48††† (−6.00 to 4.125) | −5.90 ± 2.80*** (−12.75 to 0.75) | −6.20 ± 2.42*** (−11.00 to −0.375) | −5.78 ± 2.95*** (−12.75 to 0.75) |
| IOP (mmHg ± SD, (range)) | 14.5 ± 2.7 (7.0 to 21.0) | 14.6 ± 2.7 (9.0 to 21.0) | 14.2 ± 2.6 (7.0 to 21.0) | 15.2 ± 4.2 (2.0 to 32.0) | 14.5 ± 3.7 (7.0 to 24.0) | 15.5 ± 4.3 (2.0 to 32.0) |
| CCT (μm ± SD, (range)) | 555.3 ± 32.6 (390.0 to 658.4) | 553.6 ± 33.7 (390.0 to 658.4) | 562.1 ± 26.8 (507.0 to 655.0) | 544.0 ± 41.1** (425.3 to 629.3) | 532.5 ± 39.9** (449.0 to 617.3) | 548.5 ± 40.9 (425.3 to 629.3) |
Data for each group are reported for “All Eyes” as well as for “Hi-ESF and for “Non-Hi-ESF” sub-groups (Hi-ESF eyes were defined to be those eyes in which the magnitude of the ESF subregion was ≥ 100 μm in at least one ONH sector – (see Methods). Within the Hi-Myo eyes (Right Panel), data in bold red with asterisks are significantly different from the Non-Hi-Myo value (Left Panel) for the same sub-group and remain significant using a Holm-Bonferonni correction for multiple comparisons
(p < 0.001
p < 0.01
p < 0.05, t test or Chisquare test). Within the Hi-ESF column of both groups, obelisks denote data that are significantly different from the Non-Hi-ESF eyes of the same group and remain significant using a Holm-Bonferonni correction for multiple comparisons
(p < 0.001
p < 0.01
p < 0.05, (t test or Chi-square test)).