Table 2.
Mean OCT Neuroretinal Rim, Perineural Canal Retinal Nerve Fiber Layer Thickness (pNC-RNFLT), Neural Canal, and Perineural Canal Choroidal Thickness (pNC-CT) Parameter Values by Group.
| Non-Hi-Myo-Healthy Eyes (n=362) | Hi-Myo Eyes (n=122) | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| All Eyes (n=362) | Non-Hi-ESF Eyes (n=289) | Hi-ESF Eyes (n=73) | All Eyes (n=122) | Non-Hi-ESF Eyes (n=35) | Hi-ESF Eyes (n=87) | |
| Global BMO-MRW (μm ± SD, (range)) | 333.1 ± 60.0 (190.0 to 558.3) | 334.6 ± 60.4 (190.0 to 558.3) | 327.3 ± 58.7 (213.6 to 510.4) | 235.7 ± 81.1*** (96.6 to 414.6) | 239.3 ± 100.1*** (107.0 to 414.6) | 234.3 ± 72.8*** (96.6 to 397.0) |
| Global pNC-RNFLT (12 degree) (μm ± SD, (range)) | 98.1 ± 10.1 (73.0 to 133.3) | 99.2 ± 9.9 (75.9 to 133.3) | 93.4 ± 9.3††† (73.0 to 118.3) | 76.2 ± 18.6*** (43.3 to 116.5) | 77.0 ± 19.7*** (46.2 to 116.5) | 75.9 ± 18.2*** (43.3 to 116.3) |
| BMO area (mm2 ± SD, (range)) | 1.83 ± 0.38 (1.05 to 3.46) | 1.79 ± 0.37 (1.05 to 3.46) | 1.98 ± 0.42††† (1.20 to 3.15) | 2.32 ± 0.80*** (1.07 to 5.42) | 2.04 ± 0.57 (1.07 to 3.98) | 2.44 ± 0.85***,†† (1.22 to 5.42) |
| ASCO area (mm2 ± SD, (range)) | 2.23 ± 0.43 (1.24 to 3.97) | 2.24 ± 0.44 (1.24 to 3.97) | 2.20 ± 0.42 (1.27 to 3.43) | 2.37 ± 0.74 (0.89 to 5.21) | 2.29 ± 0.64 (1.24 to 4.13) | 2.41 ± 0.77 (0.89 to 5.21) |
| BMO/ASCO area ratio (± SD, (range)) | 0.83 ± 0.11 (0.55 to 1.21) | 0.81 ± 0.09 (0.55 to 1.12) | 0.91 ± 0.11††† (0.66 to 1.21) | 0.99 ± 0.20*** (0.59 to 1.99) | 0.91 ± 0.16*** (0.66 to 1.48) | 1.03 ± 0.21***,††† (0.59 to 1.99) |
| SFO area (mm2 ± SD, (range)) | 2.16 ± 0.43 (1.09 to 3.90) | 2.21 ± 0.44 (1.19 to 3.90) | 1.97 ± 0.36††† (1.09 to 2.98) | 2.16 ± 0.66 (0.82 to 4.30) | 2.24 ± 0.65 (1.24 to 4.13) | 2.13 ± 0.66 (0.82 to 4.30) |
| NCMCA (mm2 ± SD, (range)) | 1.33 ± 0.42 (0.40 to 2.57) | 1.40 ± 0.38 (0.55 to 2.57) | 1.06 ± 0.44††† (0.40 to 2.29) | 0.86 ± 0.50*** (0.24 to 3.19) | 1.10 ± 0.59** (0.32 to 2.66) | 0.77 ± 0.43*** (0.24 to 3.19) |
| BMO ovality index (± SD, (range)) | 1.12 ± 0.07 (1.00 to 1.36) | 1.13 ± 0.07 (1.00 to 1.36) | 1.11 ± 0.05 (1.01 to 1.25) | 1.12 ± 0.08 (1.01 to 1.36) | 1.13 ± 0.08 (1.01 to 1.31) | 1.12 ± 0.08 (1.01 to 1.36) |
| ASCO ovality index (± SD, (range)) | 1.12 ± 0.06 (1.00 to 1.37) | 1.12 ± 0.07 (1.00 to 1.37) | 1.11 ± 0.05 (1.03 to 1.24) | 1.14 ± 0.08 (1.00 to 1.40) | 1.16 ± 0.10 (1.00 to 1.36) | 1.13 ± 0.08 (1.01 to 1.40) |
| SFO ovality index (± SD, (range)) | 1.13 ± 0.07 (1.01 to 1.41) | 1.13 ± 0.07 (1.01 to 1.39) | 1.16 ± 0.09 (1.01 to 1.41) | 1.19 ± 0.12*** (0.94 to 1.63) | 1.17 ± 0.10 (1.00 to 1.35) | 1.19 ± 0.13 (0.94 to 1.63) |
| NCMCA ovality index (± SD, (range)) | 1.54 ± 0.57 (1.01 to 4.49) | 1.39 ± 0.34 (1.01 to 2.90) | 2.14 ± 0.84††† (1.09 to 4.49) | 2.78 ± 1.04*** (1.11 to 6.52) | 2.15 ± 0.88*** (1.11 to 4.84) | 3.04 ± 0.99***,††† (1.12 to 6.52) |
| BMO / ASCO offset magnitude (μm ± SD, (range)) | 89.76 ± 62.34 (4.00 to 402.00) | 72.60 ± 42.40 (4.00 to 220.00) | 157.71 ± 80.29††† (16.00 to 402.00) | 253.22 ± 129.09*** (23.00 to 724.00) | 159.86 ± 100.29*** (23.00 to 506.00) | 290.78 ± 120.39***,††† (42.00 to 724.00) |
| BMO / SFO offset magnitude (μm ± SD, (range)) | 108.68 ± 86.38 (4.00 to 484.00) | 78.67 ± 48.38 (4.00 to 264.00) | 227.48 ± 100.61††† (70.00 to 484.00) | 317.34 ± 163.23*** (29.00 to 938.00) | 175.17 ± 106.74*** (29.00 to 524.00) | 374.54 ± 146.45***,††† (84.00 to 938.00) |
| Neural Canal Obliqueness (degree ± SD, (range)) | 39.73 ± 16.83 (2.00 to 76.00) | 35.81 ± 14.77 (2.00 to 70.00) | 55.23 ± 15.55††† (11.00 to 76.00) | 65.30 ± 13.65*** (16.00 to 83.00) | 55.37 ± 17.02*** (16.00 to 80.00) | 69.30 ± 9.56***,††† (16.00 to 83.00) |
| Global pNC-CT 100 (μm ± SD, (range)) | 108.85 ± 26.23 (45.00 to 194.00) | 109.13 ± 26.31 (45.00 to 194.00) | 106.81 ± 25.90 (65.00 to 175.00) | 98.69 ± 29.20*** (34.45 to 189.58) | 96.30 ± 28.28 (34.45 to 150.88) | 99.65 ± 29.67 (43.44 to 189.58) |
| Global pNC-CT 300 (μm ± SD, (range)) | 129.32 ± 37.46 (37.00 to 244.00) | 131.06 ± 37.38 (37.00 to 244.00) | 121.94 ± 37.21 (62.00 to 220.00) | 101.32 ± 30.14*** (35.08 to 169.35) | 104.62 ± 31.76*** (35.08 to 154.37) | 99.99 ± 29.56*** (40.17 to 169.35) |
| Global pNC-CT 700 (μm ± SD, (range)) | 156.49 ± 53.92 (36.00 to 296.00) | 160.17 ± 54.16 (36.00 to 296.00) | 141.65 ± 50.64 (57.00 to 273.00) | 103.67 ± 33.46*** (38.24 to 184.56) | 114.30 ± 40.09*** (39.95 to 184.56) | 99.39 ± 29.58*** (38.24 to 182.45) |
| Global pNC-CT 1100 (μm ± SD, (range)) | 172.51 ± 62.39 (40.00 to 341.00) | 177.38 ± 62.62 (40.00 to 341.00) | 151.52 ± 57.24†† (58.00 to 285.00) | 104.78 ± 36.89*** (35.22 to 192.43) | 119.16 ± 45.01*** (43.28 to 192.43) | 98.99 ± 31.55*** (35.22 to 186.07) |
Data for each group are reported for “All Eyes” as well as for “Hi-ESF and for “Non-Hi-ESF” sub-groups. Hi-ESF eyes were defined to be those eyes in which the magnitude of the ESF subregion was ≥ 100 μm in at least one ONH sector – (see Methods). Within the Hi-Myo eyes (Right Panel), data in bold red with asterisks are significantly different from the Non-Hi-Myo value (Left Panel) for the same sub-group and remain significant using a Holm-Bonferonni correction for multiple comparisons
***
(p < 0.001
**
p < 0.01
*
p < 0.05, t test). Within the Hi-ESF column of both groups, obelisks denote data that are significantly different from the Non-Hi-ESF eyes of the same group and Page 40 remain significant using a Holm-Bonferonni correction for multiple comparisons
†††
(p < 0.001
††
p < 0.01
†
p < 0.05, t test).