Table 8.
Significant Multivariable associations with the magnitude of an OCT Exposed Neural Canal (ENC) Region (Left), Externally Oblique Choroidal Border Tissue (EOCBT) Region (Middle) and Exposed Scleral Flange (ESF) Region (Right), (respectively), among All Study Eyes (n=484); All Hi-ESF Eyes (n=160) and All Hi-Myo Eyes (n=122).
| ENC | EOCBT | ESF | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| All Eyes | Hi-ESF | Hi-Myo | All Eyes | Hi-ESF | Hi-Myo | All Eyes | Hi-ESF | Hi-Myo | |
| Age | 0.14 (P=0.037) | ||||||||
| Spherical Equivalent | −1.70 (P<0.001) | ||||||||
| BMO area (0.1mm2 increase) | 10.03 (P<0.001) | 2.61 (P<0.001) | |||||||
| ASCO area (0.1mm2 increase) | −7.81 (P<0.001) | ||||||||
| BMO/ASCO area ratio | 245.65 (P<0.001) | 176.83 (P<0.001) | 151.62 (P<0.001) | 202.84 (P<0.001) | 174.69 (P<0.001) | ||||
| SFO area (0.1mm2 increase) | −2.14 (P<0.001) | ||||||||
| BMO ovality index | −157.04 (P<0.001) | −57.23 (P<0.001) | |||||||
| ASCO ovality index | −141.92 (P=0.002) | ||||||||
| SFO ovality index | 151.86 (P<0.001) | 195.70 (P<0.001) | 185.80 (P<0.001) | 39.14 (P=0.003) | 61.42 (P=0.003) | 67.51 (P=0.041) | 62.00 (P<0.001) | 86.34 (P<0.001) | 159.01 (P<0.001) |
| NCMCA ovality index | 40.26 (P<0.001) | −18.45 (P<0.001) | |||||||
| BMO / ASCO offset (100 μm increase) | 44.07 (P<0.001) | 47.84 (P<0.001) | 28.07 (P<0.001) | 30.16 (P<0.001) | 25.46 (P<0.001) | ||||
| BMO / SFO offset (100 μm increase) | 17.99 (P<0.001) | 31.70 (P<0.001) | 31.53 (P<0.001) | ||||||
| Neural Canal Obliqueness | 0.87 (P<0.001) | −1.30 (P<0.001) | |||||||
| Global pNC-CT 300 | 0.27 (P<0.001) | ||||||||
Within this analysis, data for each eye and each ENC, EOCBT or ESF region include the sectoral values for that region in all 12 sectors - with sectoral values in which there is no ENC, no EOCBT or no ESF, (respectively) being treated as zero (0). Taken together these data strongly suggest that axial length and spherical equivalent are poor surrogates for predicting the magnitude and regional composition of myopic neural canal structural remodeling as described by the parameters of this report. Likewise, the single parameter SFO ovality index was associated with the magnitude of each ENC region, (and strongly associated with the ESF region), in all three groups of Study eyes. (Variables with no significant correlations included: Female Gender, Left Eye, Axial length, Intraocular Pressure, Central Corneal Thickness, Mean deviation, Global BMO-MRW, Global pNC-RNFLT and Neural Canal Minimum Cross-sectional Area. See Table 7 and Supplemental Tables 4 and 5 for the expanded Univariable and Multivariable association data that are summarized herein).