Figure 3:

Primary Outcome by change in encephalopathy from qualifying Sarnat exam (qSE) to exam after rewarming (rSE). In the Normal/Mild group, n=205 (65%) experienced disability-free survival, n=43 (14%) mild NDI, n=46 (15%) moderate NDI, n=19 (6%) severe NDI, and n=1 (0%) died. In the Moderate->Moderate group, n=22 (36%) experienced disability-free survival, n=7 (11%) mild NDI, n=14 (23%) moderate NDI, n=16 (26%) severe NDI, and n=3 (5%) died. In the Severe->Moderate group, n=6 (19%) experienced disability-free survival, n=2 (6%) mild NDI, n=6 (19%) moderate NDI, n=9 (29%) severe NDI, and n=8 (26%) died. In the Moderate -> Severe group, n=2 (10%) experienced disability-free survival, n=3 (15%) mild NDI, n=2 (10%) moderate NDI, n=7 (35%) severe NDI, and n=6 (30%) died. In the Severe->Severe group, n=1 (3%) each experienced no NDI, mild NDI, and moderate NDI, with n=3 (9%) experiencing severe NDI and n=27 (82%) died. aORs with 95% CI for the HEAL primary outcome (death/NDI) are shown above the plot for each group compared to infants who improved from moderate or severe on qSE to mild or normal on rSE. Models are adjusted for medications prior to assessment and ECMO. NDI = Neurodevelopmental Impairment; HIE = Hypoxic-ischemic encephalopathy; ECMO = Extracorporeal Membrane Oxygenation.