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. Author manuscript; available in PMC: 2025 Apr 18.
Published in final edited form as: Cell Chem Biol. 2023 Dec 6;31(4):805–819.e9. doi: 10.1016/j.chembiol.2023.11.007

Figure 1: Chemical screen identifies subtype-selective compounds.

Figure 1:

(A) Heatmap of z-scores from row-normalized IC50 values. Compounds ranked on ratio of average IC50 of MYCNA cells over MESN cell line models.

(B) Western blot of MYCN protein expression in MYCNA and MESN cell lines.

(C) Dose-response curves from four NBL cell lines treated for 48 h. Data represent the mean from three replicate experiments, and error bars represent standard deviation across experiments (mean ± S.D.).

(D) Chemical structures of four subtype-selective compounds.