Figure 2.

Intratumor microbiome communities are significantly different between R and NR patients

(A) Bar plots of the phylum (left) and genus (right) taxonomic levels in R and NR patients with lung cancer. Relative abundance is used.

(B) Phylum differences between R and NR patients.

(C) LDA score of features with different abundances between R and NR groups. The criteria for differential feature is an LDA score >2.5.

(D) Kaplan-Meier estimates for RFS probability of patients with different abundances of intratumor microbes. Left, Anaerostipes, Helicobacter, and Flavonifractor; right, Coprococcus, Gardnerella, and Roseburia.

(E) Six differentially abundant genera in genus predicting score.

(F) Kaplan-Meier plot of patients with lung cancer defined by genus predicting score.

(G) ROC analysis of genus predicting score as predictive of RFS.

R, recurrence group; NR, non-recurrence group; T, tumor tissues; N, normal lung tissues; LDA, linear discriminant analysis; RFS, recurrence-free survival; ROC, receiver operating characteristics. The error bars indicate the standard deviations. See also Figure S2.