Extended Data Table 6.

Comparison of estimates from multiple imputed data using MICE models, with estimates from complete case analysis for secondary outcomes at 3 and 5 months

CI, confidence interval; EQ-5D-5L, 5-level EuroQol health-related quality of life questionnaire; GAD-7, 7-item General Anxiety Disorder questionnaire; ICECAP-O, ICEpop CAPability measure for older people; PHQ-9, Patient Health Questionnaire-9; 3-item UCLA, University of California, Los Angeles.

PHQ-9 scores range from 0 to 27, with higher scores representing more severe depressive symptomatology.

GAD-7 scores range from 0 to 21, with higher scores representing more severe anxiety symptomatology.

EQ-5D-5L scores range from −0.264 to 1, with higher scores representing higher quality of life.

ICECAP-O scores range from 0 to 1, with higher scores representing greater levels of capability well-being.

3-item UCLA scores range from 3 to 9, with higher scores representing more severe levels of loneliness.

^aDifferences in means were estimated using linear regression models, adjusted for relevant baseline assessment of corresponding outcome, sex, age group and baseline severity of PHQ-9 (categorical).

^bAll estimates had missing data imputed seperately, according to trial arm, using MICE models that included predictors of missingness, sex, age group and baseline severity of the PHQ-9 score (categorical).

^cAll P values reported are based on two-sided t-tests from the relevant linear regression model, with no adjustments for multiple tests.