. 2024 Mar 14;30(4):1127–1133. doi: 10.1038/s41591-024-02864-4

Table 4.

CACE analyses on the mean PHQ-9 scores at the 3-month and 5-month follow-ups using electronic recordings

Threshold	3-month follow-up		5-month follow-up
Threshold	Adjusted difference in mean PHQ-9 (95% CI)^a,b	P^c	Adjusted difference in mean PHQ-9 (95% CI)^a,b	P^c
Opened at least 24 messages (n = 237, 79.5%)	−1.52 (−3.06–0.02)	0.053	−0.49 (−1.98–0.99)	0.513
Opened at least 36 messages, that is, the minimum therapeutic dose (n = 226, 75.8%)	−1.59 (−3.21–0.02)	0.054	−0.52 (−2.08–1.04)	0.513
Opened all 48 messages (n = 173, 58.1%)	−2.09 (−4.20–0.03)	0.053	−0.68 (−2.71–1.35)	0.513

PHQ-9 scores range from 0 to 27, with higher scores representing more severe depressive symptomatology.

^aAll models are adjusted for stratification (sex, age group and baseline severity of PHQ-9 score (categorical)).

^bAll estimates had missing data imputed separately, according to trial arm, using MICE models that included predictors of missingness (extended data), stratification (sex, age group and baseline severity of PHQ-9 score (categorical)).

^cAll P values reported are based on two-sided t-tests from the relevant CACE regression model, with no adjustments for multiple tests.