Extended Data Table 1.

Concordance of fluid and imaging biomarkers of Aβ and tau pathologies

Concordance of fluid biomarkers with Aβ and tau PET positivity in BioFINDER-2 and Knight ADRC participants. AUCs for all, cognitively impaired and cognitively unimpaired groups are shown from left to right. The number of negative (controls) and positive (cases) imaging-based groups are shown in each case. Differences between the statistics using plasma %p-tau217 (reference) and CSF biomarkers are shown together with the mean values. We considered plasma and CSF biomarkers clinically equivalent if the 95% CI of the mean difference included zero and clinically superior if it did not include zero and favored plasma (>0). Aβ PET positivity was assessed as Centiloids ≥ 37. Tau PET positivity was assessed using in-house previously validated cutoffs (SUVR > 1.32 for both cohorts in Braak I–IV). Ctrl, control.