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. 2024 Apr 11;30(4):990–1000. doi: 10.1038/s41591-024-02848-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — (a) Overall response distributions of therapeutic response prior to study enrollment in TPC cohort and FPM-guided patients. P values from two-sided Barnard’s test comparing ORR. (b) Kaplan-Meier survival curves of previous regimen PFS in TPC and FPM-guided patients. P values from Logrank test analysis of PFS data. (c) OR distributions of previous versus current regimen in TPC cohort. P values from two-sided McNemar’s Paired test comparing ORR. (d) Kaplan-Meier survival curves of the previous versus current regimen PFS in TPC cohort. P values from two-sided Cox Proportional Hazard test analysis of paired PFS data. PR = Previous Regimen, TPC = Treatment of Physician’s Choice, FPM = FPM-guided.