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a–d, C-statistics of Cox models of disease-specific CRFs and PRSs for incident CAD (n = 5,093) (a), T2D (n = 5,297) (b), AD (n = 5,347) (c) and prostate cancer (n = 2,464) (d). CRFs and PRSs are modeled individually and jointly. Cox proportional hazard models for CAD, T2D and AD are stratified by sex. The C-statistics are depicted alongside their 95% CIs as dots and error bars.
