Table 3.
Medication abortion additional interventions and serious adverse events
| Effectiveness and safety outcomes | n = 4,454 | Complete case n = 4,454 | Imputeda n = 6,034 |
|---|---|---|---|
| No. | Estimate (95% CI) | Estimate (95% CI) | |
| Effectiveness | |||
| Complete abortion without intervention | 4,351 | 97.7 (97.2–98.1) | 97.7 (97.2–98.1) |
| Intervention to complete abortionb | 103 | 2.3 (1.9–2.8) | 2.3 (1.9–2.8) |
| Procedure, aspiration or surgery | 63 | 1.4 (1.1–1.8) | 1.4 (1.1–1.8) |
| Prescribed >1,600 μg misoprostol, mifepristone or other medications | 22 | 0.49 (0.29–0.70) | 0.56 (0.32–0.81) |
| Treatment for an ectopic pregnancyc | 6 | 0.13 (0.03–0.24) | 0.16 (0.01–0.31) |
| Suspected or confirmed continuing pregnancy | 41 | 0.92 (0.64–1.20) | 0.94 (0.65–1.23) |
| Safety | |||
| No major abortion-related adverse eventsc | 4,439 | 99.7 (99.5–99.8) | 99.8 (99.6–99.9) |
| Major abortion-related adverse eventsb,c | 15 | 0.34 (0.17–0.51) | 0.25 (0.12–0.37) |
| Blood transfusionc | 6 | 0.13 (0.03–0.24) | 0.10 (0.02–0.18) |
| Other major surgery, including treatment of an ectopic pregnancyc | 1 | 0.02 (0–0.07) | 0.02 (0–0.05) |
| Hospital admissionc | 10 | 0.22 (0.09–0.36) | 0.17 (0.06–0.27) |
| Other outcomes | |||
| Emergency department visits | 81 | 1.8 (1.4–2.2) | 1.3 (1.1–1.6) |
aImputation models included patient age, urbanicity, whether the patient obtained screening ultrasonography, whether the patient obtained synchronous or asynchronous telehealth care, whether the patient participated in the CHAT study surveys or a virtual clinic, and whether the patient used an abortion fund to pay for any portion of their abortion.
bSubcategories are not mutually exclusive.
cOutcomes are unadjusted because of small cells.
Models for estimates with n > 15 were adjusted for synchronous versus asynchronous care, patient age, race, ethnicity or ethnic grouping, urbanicity, previous abortion, pregnancy duration at intake and pre-abortion screening ultrasonography. Estimates were calculated from logistic regression models with missing outcomes and covariates imputed using multiple imputation with chained equations.