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. 2024 Mar 19;30(4):1023–1034. doi: 10.1038/s41591-024-02877-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (a) Representative radiotherapy plan of patient CGES26 who experienced adrenal insufficiency toxicity. Radiotherapy DICOMs are shown in representative axial, sagittal and coronal slices. (b) Dose volume histogram (DVH) of target and normal structures; all target and normal structure dose objectives met protocol-specified markers of plan quality, which mirror national guidelines. (c) DVH of right, left and combined adrenal glands; listed below the DVH are dose statistics (max, mean) for adrenal glands. As there are no metrics for goal dose in adrenal glands in the literature, these are contoured and reported after therapeutic radiation administration.