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. 2024 Apr 3;5(4):101490. doi: 10.1016/j.xcrm.2024.101490

Figure 4.

Figure 4

Hypothesis-driven analysis from a proteome-wide measurement performed on 166 samples from PwMS enrolled in the ReBUILD trial (Olink, Uppsala, Sweden). Relative protein concentration is reported as normalized protein expression (NPX) on a log-2 scale for each protein. Mixed models were corrected for longitudinal sampling, age at screening, and sex. Synaptosome-associated protein of 25 kDa (SNAP-25) NPX showed a strong positive association with myelin oligodendrocyte glycoprotein (MOG) (A), oligodendrocyte glycoprotein (OMgp) (B), glial fibrillary acidic protein (GFAP) (C), and chitinase 3-like 1 (CHI3L1) (D). False discovery rate (FDR)-adjusted p values remained significant for MOG (0.005), GFAP (0.013), and CHI3L1 (0.023). Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) (E), CD27 (F), and chemokine ligand 13 (CXCL-13) (G) did not correlate with SNAP-25 levels.