Figure 3.
Differential taxa identified and lung cancer detection model development
(A) The NMDS plot showing beta diversity based on the Bray-Curtis distance between HC and LC groups. Significant differences were observed between LC patients and HCs with Adonis test (R2 = 0.027, p = 0.001).
(B) Taxonomic cladogram from LEfSe showed significantly different taxa enriched in the HC and LC groups (the top 30 according to LDA).
(C) LEfSe identified significantly differentially abundant species in the HC and LC groups (the top 30 according to LDA).
(D) The receiver operating characteristic curve showed an AUC value of 95.6% in the training cohort.
(E) The receiver operating characteristic curve of 5-fold cross-validation in predicting LC with different tumor size subgroups, the subgroup with smaller tumors (<1 cm, red line), and the subgroup with larger tumors (≥1 cm, green line).