Figure 4.

Independent validation of the lung cancer detection model

(A) The receiver operating characteristic curve evaluating the performance of the LC detection model in the combined validation cohort and its validation I and II cohorts separately.

(B) Sensitivities of the LC detection model are 87.7% for the combined validation cohort, 87.5% for the validation I, and 87.9% for the validation II, respectively.

(C) The boxplots showing the distribution of cancer scores in the LC and HC groups of the independent validation cohorts. The cutoff score for the independent validation I set is 0.511, and a Wilcoxon test was performed for the comparison between LC and HC subsets.

(D) The boxplots showing the distribution of cancer scores in additional shallow-coverage validation dataset with the coverage depth of 1×, compared to WGS data of 5×. Error bars represent each group’s mean ± SD.