FIG. 2.

Multiple alignment of amino acid sequences of the RT of 16 HIV-1 group O isolates. The top line corresponds to the group O consensus amino acid sequence. Six full-length HIV-1 group O RT sequences, 3 from the database and 3 from this study, as well as 12 annotated RT sequences containing just the polymerase domain, were used in this alignment. Only those amino acids that differ from the consensus are given. Dots indicate the same residues compared with the group O consensus sequence, and plus signs denote synonymous substitutions in the RT polymerase domain. Residues involved in resistance to RT inhibitors (16, 36) are marked at the top (∧), and some of them are numbered. The polymerase and RNase H domains (24) are boxed.