Table 3.
Health-related quality of life in patients with early-onset and late-onset colorectal cancer
| Number of items | Overall (N = 4572) | EOCRC, < 50 years (N = 991) | LOCRC, ≥ 50 years (N = 3705) | P value | |
|---|---|---|---|---|---|
| Overall HRQOL * | 128.18 (24.72) | 127.63 (24.52) | 128.33 (24.77) | 0.441 | |
| FACT-C ¶ | 36 | ||||
| Physical well-being | 10 | 31.53 (5.85) | 31.25 (6.12) | 31.61 (5.77) | 0.082 |
| Social/Family well-being | 7 | 22.98 (5.69) | 23.04 (5.61) | 22.97 (5.71) | 0.722 |
| Emotional well-being | 5 | 14.89 (4.33) | 14.75 (4.49) | 14.92 (4.28) | 0.262 |
| Functional well-being | 7 | 14.69 (6.95) | 14.85 (6.84) | 14.65 (6.98) | 0.410 |
| Colorectal cancer subscale | 7 | 17.79 (4.55) | 17.90 (4.48) | 17.76 (4.57) | 0.368 |
| EORTC QLQ-C30 | 9 | ||||
| Functional scales and/or items ¶ | |||||
| Physical | 1 | 3.44 (1.02) | 3.60 (0.90) | 3.39 (1.05) | < 0.001 |
| Cognitive | 1 | 3.10 (1.00) | 3.10 (1.03) | 3.11 (0.99) | 0.924 |
| Emotional | 2 | 6.24 (1.79) | 6.05 (1.91) | 6.30 (1.76) | < 0.001 |
| Social | 2 | 5.25 (2.20) | 5.04 (2.30) | 5.31 (2.17) | 0.001 |
| Symptom items § | |||||
| Fatigue | 1 | 0.89 (1.05) | 0.83 (1.03) | 0.90 (1.05) | 0.051 |
| Sleep disturbance | 1 | 1.15 (1.16) | 1.18 (1.19) | 1.14 (1.16) | 0.349 |
| Financial impacts | 1 | 1.58 (1.24) | 1.79 (1.29) | 1.52 (1.22) | < 0.001 |
Values are presented as mean (standard deviations)
*A higher score indicates a better quality of life
¶A higher score indicates a higher level of functioning
§A higher score indicates a greater degree of symptoms