Table 4.
Distribution of L-PF-35 Dyspnea change scores at week 26 for subjects who worsened or not according to each anchor
| Anchor | N | Anchor Baseline Value Mean/Median |
Difference in L-PF-35 Dyspnea Score from Baseline to 26 Weeks (Baseline minus 26 weeks; negative = worsened) |
||||
|---|---|---|---|---|---|---|---|
| 10th Percentile |
25th Percentile |
50th Percentile |
75th Percentile |
90th Percentile |
|||
| UCSD | |||||||
|
-Worse -Not |
14 26 |
52.3 ± 19.2, 53.5 (34.0,74.0) 38.7 ± 28.1, 42.0 (11.0,60.0) |
-52.4 -16.7 |
-24.4 -7.14 |
-12.5 0.0 |
2.4 4.2 |
17.9 10.7 |
| SGRQa | |||||||
|
-Worse -Not |
20 20 |
61.9 ± 22.0, 66.2 (51.3,79.4) 59.4 ± 27.2, 69.9 (44.6,79.7) |
-43.2 -12.2 |
-24.3 -2.2 |
-10.3 1.5 |
-1.8 8.3 |
2.1 25.6 |
| FVC% | |||||||
|
-Worse -Not |
12 28 |
55.9 ± 11.4, 55.5 (50.0,59.0) 63.4 ± 11.5, 64.0 (59.0,67.5) |
-52.4 -20.0 |
-30.2 -7.1 |
-17.5 0.0 |
-1.8 5.0 |
2.4 17.9 |
| DLCO% | |||||||
|
-Worse -Not |
15 25 |
55.2 ± 11.1, 55.0 (48.0,66.0) 51.2 ± 16.8, 48.0 (40.0,58.0) |
-52.4 -26.4 |
-21.4 -8.3 |
-4.2 0.0 |
0.0 5.8 |
4.2 17.6 |
FVC% = percentage of the predicted forced vital capacity; DLCO% = percentage of the predicted diffusing capacity of the lung for carbon monoxide; L-PF = 35-item Living with Pulmonary Fibrosis Questionnaire; SGRQa = St. George’s Respiratory Questionnaire Activity domain; UCSD = University of California San Diego Shortness of Breath Questionnaire