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. Author manuscript; available in PMC: 2024 Apr 20.
Published in final edited form as: J Am Coll Cardiol. 2020 Sep 1;76(9):1084–1101. doi: 10.1016/j.jacc.2020.06.070

CENTRAL ILLUSTRATION. Pathophysiology, Medical Management, and Use of Renal Replacement Therapy in Severe Acute Kidney Injury and Refractory Cardiorenal Syndrome.

CENTRAL ILLUSTRATION

Cardiorenal syndrome (CRS) involves the interplay between hemodynamic, inflammatory, and neurohumoral abnormalities to produce worsening heart and kidney function. Management of patients with CRS involves multidisciplinary care, starting with medical management and avoidance of further acute kidney injury (AKI). For medically refractory CRS and severe AKI, renal replacement therapy, including continuous renal replacement therapy (CRRT), may be necessary.